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Merck
CN

H5395

Hydrocortisone 17-valerate

analytical standard

Synonym(s):

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate, Cortisol 17-valerate

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About This Item

Empirical Formula (Hill Notation):
C26H38O6
CAS Number:
57524-89-7
Molecular Weight:
446.58
NACRES:
NA.24
PubChem Substance ID:
329815218
UNSPSC Code:
41116107
EC Number:
260-786-8
MDL number:
MFCD00083365

Key Documents

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InChI key

FZCHYNWYXKICIO-FZNHGJLXSA-N

InChI

1S/C26H38O6/c1-4-5-6-22(31)32-26(21(30)15-27)12-10-19-18-8-7-16-13-17(28)9-11-24(16,2)23(18)20(29)14-25(19,26)3/h13,18-20,23,27,29H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCC)C(=O)CO

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

Quality Level

200

Gene Information

human ... NR3C1(2908)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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K M Tramposch
Inflammation, 17(5), 531-536 (1993-10-01)
Synthetic glucocorticosteroids are widely used in clinical dermatology in the treatment of a number of inflammatory skin disorders. However, cutaneous side effects such as induction of skin atrophy are among the factors that limit the chronic use of this class
J G Alford et al.
Agents and actions, 37(3-4), 260-267 (1992-11-01)
We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by edema, cell infiltration and epidermal hyperplasia. In order to characterize the cell infiltrate during the establishment
'Eye-catching' dermatitis for the skin surgeon.
R K Roenigk
Ophthalmic plastic and reconstructive surgery, 15(3), 149-150 (1999-06-04)
Contact allergic reaction to valerate esters of betamethasone and hydrocortisone.
E M Koch
Contact dermatitis, 12(1), 58-58 (1985-01-01)
R C Cornell
International journal of dermatology, 31 Suppl 1, 38-40 (1992-10-01)
It would be desirable to develop an alternative system to clinical studies to evaluate the potency of generic topical corticosteroids and of new formulations of existing innovator corticosteroids. The vasoconstrictor assay is a reliable method for testing potency; however, its
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