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Merck
CN

H5395

Supelco

Hydrocortisone 17-valerate

analytical standard

Synonym(s):

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate, Cortisol 17-valerate

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About This Item

Empirical Formula (Hill Notation):
C26H38O6
CAS Number:
57524-89-7
Molecular Weight:
446.58
EC Number:
260-786-8
MDL number:
MFCD00083365
UNSPSC Code:
41116107
PubChem Substance ID:
329815218
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCC)C(=O)CO

InChI

1S/C26H38O6/c1-4-5-6-22(31)32-26(21(30)15-27)12-10-19-18-8-7-16-13-17(28)9-11-24(16,2)23(18)20(29)14-25(19,26)3/h13,18-20,23,27,29H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1

InChI key

FZCHYNWYXKICIO-FZNHGJLXSA-N

Gene Information

human ... NR3C1(2908)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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A comparison of once-daily application of mometasone furoate 0.1% cream compared with twice-daily hydrocortisone valerate 0.2% cream in pediatric atopic dermatitis patients who failed to respond to hydrocortisone: mometasone furoate study group.
M Lebwohl
International journal of dermatology, 38(8), 604-606 (1999-09-16)
Contact allergic reaction to valerate esters of betamethasone and hydrocortisone.
E M Koch
Contact dermatitis, 12(1), 58-58 (1985-01-01)
M E Lutz et al.
Journal of the American Academy of Dermatology, 38(5 Pt 1), 691-695 (1998-05-20)
Tixocortol pivalate is an established marker to topical corticosteroid allergy. The prevalence of tixocortol pivalate hypersensitivity is well established in Europe, where exposure to this corticosteroid as a therapeutic agent varies. In the United States, tixocortol pivalate is not commercially
S N Horwitz et al.
Journal of the American Academy of Dermatology, 13(5 Pt 1), 784-791 (1985-11-01)
A double-blind parallel group study was undertaken to assess the effect of adding a topically applied corticosteroid cream to a modified Goeckerman regimen to treat patients with psoriasis. Nineteen patients with psoriasis were treated with either this regimen and hydrocortisone
M V Dahl et al.
Archives of dermatology, 120(12), 1595-1597 (1984-12-01)
A 47-year-old man had a generalized, eczematous erythroderma and eosinophilia one week after a wasp sting. These changes persisted for four months despite intensive topical therapy and oral corticosteroids. He was then given corticosteroid pulse therapy with methylprednisolone sodium succinate
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