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PHR1400

Mometasone Furoate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Mometasone furoate, 9α,21-dichloro-11β-hydroxy-16α-methyl 3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate, (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C27H30Cl2O6
CAS Number:
83919-23-7
Molecular Weight:
521.43
NACRES:
NA.24
PubChem Substance ID:
329823374
UNSPSC Code:
41116107
MDL number:
MFCD00866003

Key Documents

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InChI

1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl

InChI key

WOFMFGQZHJDGCX-ZULDAHANSA-N

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. M2900000, traceable to USP 1445470

API family

mometasone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... NR3C1(2908)

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General description

Mometasone Furoate is a medication with anti-inflammatory and antipruritic properties, commonly used to treat mixed infections of the skin. It is also used as a corticosteroid for the treatment of asthma and its mode of action involves reducing the inflammation of the airways and preventing the loss of lung functions.

Application

Mometasone Furoate may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Mometasone furoate is an anti-inflammatory glucocorticoid.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3330 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous estimation of Nadifloxacin and Mometasone Furoate in topical cream by HPTLC method
Kulkarni AA, et al.
Der Pharma Chemica, 2(3), 25-30 (2010)
Validated chromatographic methods for the simultaneous determination of Mometasone furoate and Formoterol fumarate dihydrate in a combined dosage form
Merey AH, et al.
Bulletin of Faculty of Pharmacy, Cairo University , 54(1), 99-106 (2016)
Validated high-performance thin-layer chromatographic (HPTLC) method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate cream using fractional factorial design
Patel GK, et al.
Journal of food and drug analysis, 24(3), 610-619 (2016)
Anthony D'Urzo
Expert opinion on pharmacotherapy, 8(16), 2871-2884 (2007-10-25)
Mometasone furoate dry-powder inhaler (MF-DPI) is an inhaled corticosteroid (ICS) used for the treatment of persistent asthma in patients aged >or= 12 years. MF-DPI has low systemic bioavailability and high glucocorticoid receptor affinity compared with most other ICSs and modifies
Christian Grabow Westergaard et al.
Expert opinion on pharmacotherapy, 14(3), 339-346 (2013-02-01)
Asthma is a common chronic respiratory disease affecting the airways causing inflammation, airway hyperreactivity (AHR), and respiratory symptoms. Frequently, asthma can be effectively treated with inhaled corticosteroids (ICS) but in more severe cases additional drugs are required, such as long-acting
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