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PHR1630

Supelco

Prednisolone Acetate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Prednisolone 21-acetate, 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate, 21-Acetoxy-1,4-pregnadiene-11β,17α-diol-3,20-dione
Empirical Formula (Hill Notation):
C23H30O6
CAS Number:
52-21-1
Molecular Weight:
402.48
Beilstein:
3111798
EC Number:
200-134-1
MDL number:
MFCD00037710
PubChem Substance ID:
329823520
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to BP 1140
traceable to Ph. Eur. P2800000
traceable to USP 1556008

API family

prednisolone

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

LRJOMUJRLNCICJ-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Prednisolone Acetate belongs to the group of glucocorticoids, widely used to treat allergic and inflammatory conditions of the eyes.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Prednisolone Acetate may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0028 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

PHR1043

Prednisolone, Pharmaceutical Secondary Standard; Certified Reference Material

P2700000

Prednisolone, European Pharmacopoeia (EP) Reference Standard

P2800000

Prednisolone acetate, European Pharmacopoeia (EP) Reference Standard

P2810000

Prednisolone sodium phosphate, European Pharmacopoeia (EP) Reference Standard

Y0001355

Prednisolone for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001359

Prednisolone for peak identification, European Pharmacopoeia (EP) Reference Standard

P2805000

Prednisolone pivalate, European Pharmacopoeia (EP) Reference Standard

Y0000582

Prednisolone acetate for peak identification, European Pharmacopoeia (EP) Reference Standard

1557000

Prednisolone sodium phosphate, United States Pharmacopeia (USP) Reference Standard

1555005

Prednisolone, United States Pharmacopeia (USP) Reference Standard

1556008

Prednisolone acetate, United States Pharmacopeia (USP) Reference Standard

1556507

Prednisolone hemisuccinate, United States Pharmacopeia (USP) Reference Standard

1558003

Prednisolone tebutate, United States Pharmacopeia (USP) Reference Standard

BP464

Prednisolone, British Pharmacopoeia (BP) Assay Standard

BP292

Prednisolone sodium phosphate, British Pharmacopoeia (BP) Assay Standard

BP1140

Prednisolone acetate, British Pharmacopoeia (BP) Reference Standard

PHR2556

Prednisolone Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard

PHR2557

Prednisolone Impurity I, certified reference material, pharmaceutical secondary standard

PHR2328

Prednisolone Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2816

Prednisolone Sodium Phosphate, certified reference material, pharmaceutical secondary standard

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

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Stability indicating HPLC method for the simultaneous determination of moxifloxacin and prednisolone in pharmaceutical formulations
Razaaq NS, et al.
Chemistry Central Journal, 6(1), 94-94 (2012)
Mohammed Shahid Ali et al.
Journal of chromatographic science, 40(8), 429-433 (2002-10-22)
A simple, specific, and precise high-performance liquid chromatographic method has been developed for the simultaneous determination of ofloxacin (OFX), tetrahydrozoline hydrochloride (THC), and prednisolone acetate (PAC) in ophthalmic suspension using propylparaben (POP) as the internal standard. The mobile phase consists

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