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PHR1663

Supelco

Propofol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
2,6-Diisopropylphenol, 2,6-Bis(isopropyl)phenol, Propofol, 2,6-Bis(1-methylethyl)phenol
Linear Formula:
[(CH3)2CH]2C6H3OH
CAS Number:
Molecular Weight:
178.27
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor pressure

5.6 mmHg ( 100 °C)

CofA

current certificate can be downloaded

packaging

ampule of 1 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.514 (lit.)

bp

256 °C/764 mmHg (lit.)

mp

18 °C (lit.)

density

0.962 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 1031
traceable to PhEur Y0000016
traceable to USP 1572503

storage temp.

2-8°C

SMILES string

CC(C)c1cccc(C(C)C)c1O

InChI

1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3

InChI key

OLBCVFGFOZPWHH-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Propofol is approved for induction and maintenance of paediatric anesthesia and sedation in children less than 3 years of age. The mechanism of action involves interaction with gamma-aminobutyric acid A receptor. Rapid effect and fewer side effects like postoperative nausea makes propofol a popular intravenous anesthetic agents.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Propofol may be used as a pharmaceutical reference standard for the determination of the analyte in emulsion dosage form by sequential injection technique with spectrophotometric and fluorimetric detections.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA5999 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Certificate of Analysis

Certificate of Origin

Propofol: a review of its role in pediatric anesthesia and sedation
Chidambaran V, et al.
CNS Drugs, 29(7), 543-563 (2015)
Fully automated analytical procedure for propofol determination by sequential injection technique with spectrophotometric and fluorimetric detections
Sramkova I, et al.
Talanta, 118, 104-110 (2014)

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