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PHR2407

Supelco

N-Nitrosodimethylamine

Synonym(s):
N-Nitrosodimethylamine, Dimethylnitrosamine
Linear Formula:
(CH3)2NNO
CAS Number:
Molecular Weight:
74.08
MDL number:

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor pressure

5 mmHg ( 20 °C)

description

Pharmaceutical Secondary Standard; Certified Reference Material

CofA

current certificate can be downloaded

packaging

pkg of 100 mg

refractive index

n20/D 1.437 (lit.)

bp

153 °C/774 mmHg (lit.)

density

1.01 g/mL (lit.)

storage temp.

2-8°C

SMILES string

CN(C)N=O

InChI

1S/C2H6N2O/c1-4(2)3-5/h1-2H3

InChI key

UMFJAHHVKNCGLG-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Biochem/physiol Actions

Induces gastric, liver, kidney and lung cancer in mice and rats.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4355 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Carc. 1B - STOT RE 1

Target Organs

Liver

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

141.8 °F - closed cup

Flash Point(C)

61.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Articles

Determination of N-Nitrosamines in Valsartan

Nitrosamines have been discovered as a serious contaminant group in active pharmaceutical ingredients (API) belonging to the sartan family. This article describes a GC-MS method for the determination of nitrosamines in Valsartan tablets according to US FDA guide lines that can be used for pharma QC.

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