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Merck
CN

M6524

Sigma-Aldrich

Methoxamine hydrochloride

α1-adrenoceptor agonist

Synonym(s):

α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C11H17NO3 · HCl
CAS Number:
61-16-5
Molecular Weight:
247.72
EC Number:
200-499-7
MDL number:
MFCD00058607
UNSPSC Code:
12352116
PubChem Substance ID:
24277785
NACRES:
NA.77

Key Documents

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Product Name

Methoxamine hydrochloride,

storage temp.

2-8°C

SMILES string

Cl[H].COc1ccc(OC)c(c1)C(O)C(C)N

InChI

1S/C11H17NO3.ClH/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3;/h4-7,11,13H,12H2,1-3H3;1H

InChI key

YGRFXPCHZBRUKP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Related Categories

Biochem/physiol Actions

α1-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000434852
0000434852
0000385127
0000374683
0000324452

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Manuel Hernández-Guerra et al.
Hepatology (Baltimore, Md.), 57(4), 1564-1574 (2012-11-24)
Chronic intermittent hypoxia (CIH) occurs with obstructive sleep apnea syndrome (OSAS) and provokes systemic endothelial dysfunction, which is associated with oxidative stress and low nitric oxide (NO) bioavailability. Cirrhotic livers exhibit intrahepatic endothelial dysfunction, which is characterized by an impaired
Alain Frigon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(15), 5579-5588 (2011-04-15)
Extra forces or torques are defined as forces or torques that are larger than would be expected from the input or stimuli, which can be mediated by properties intrinsic to motoneurons and/or to the muscle. The purpose of this study
ShiYong Huang et al.
Neuron, 73(3), 497-510 (2012-02-14)
Neuromodulatory input, acting on G protein-coupled receptors, is essential for the induction of experience-dependent cortical plasticity. Here we report that G-coupled receptors in layer II/III of visual cortex control the polarity of synaptic plasticity through a pull-push regulation of LTP
Lindsay D MacKenzie et al.
The journal of sexual medicine, 8(9), 2461-2471 (2011-06-29)
Mean arterial pressure (MAP) and specific regulation of penile blood flow are the primary determinants of an erection. While this concept is well recognized, the differential relationship between systemically acting vasoactive factors on arterial pressure and erectile responses is not
R H Lee et al.
Journal of neurophysiology, 81(5), 2164-2174 (1999-05-13)
Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha1 agonist methoxamine. Like many types of motoneurons, spinal motoneurons in the adult mammal can exhibit bistable behavior. This means that short periods of excitatory input can initiate long
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Articles

α1-Adrenoceptor Characteristics and Modulators

Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.

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