N115
Naltrindole hydrochloride
≥97.5% (HPLC), solid, δ-opioid receptor antagonist
Synonym(s):
NTI hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H26N2O3 · HCl
CAS Number:
Molecular Weight:
450.96
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Naltrindole hydrochloride, solid
form
solid
Quality Level
storage condition
desiccated
color
off-white
solubility
methanol: 4.5 mg/mL, H2O: 8 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8
InChI
1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1
InChI key
KNJKRQXCFJCQHC-IDRHMUJXSA-N
Gene Information
human ... OPRD1(4985)
Biochem/physiol Actions
Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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W Bilecki et al.
European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term
J L Nano et al.
Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
P S Portoghese et al.
European journal of pharmacology, 146(1), 185-186 (1988-01-27)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N115-5MG | 04061832557366 |
| N115-50MG | 04061832557359 |
| N115-10MG | 04061832557342 |