A3281
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Synonym(s):
W-7
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About This Item
Empirical Formula (Hill Notation):
C16H21ClN2O2S · HCl
CAS Number:
Molecular Weight:
377.33
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6030174
Form:
powder
Quality level:
form
powder
Quality Level
mode of action
cell membrane | interferes, enzyme | inhibits
storage temp.
−20°C
SMILES string
Cl[H].NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI key
OMMOSRLIFSCDBL-UHFFFAOYSA-N
Gene Information
human ... CAMK2A(815), CAMK2B(816)
Application
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.
Biochem/physiol Actions
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is a calmodulin antagonist. It can prevent calcium-dependent protein kinase, that is sensitive to phospholipid.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
M Osawa et al.
FEBS letters, 442(2-3), 173-177 (1999-02-03)
Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7). The radius of gyration was 17.4+/-0.3 A for Ca2+/CaM-W-7 with a molar ratio
S M H Alavi et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 160(2), 166-174 (2011-06-10)
The present study shows the roles of osmolality, calcium (Ca(2+))-potassium (K(+)) antagonist and Ca(2+) in sperm activation and flagellar beating of a sturgeon species, sterlet (Acipenser ruthenus). Sperm motility was activated at hypoosmolality relative to seminal plasma and suppressed at
Yukiomi Tsuji et al.
Circulation, 123(20), 2192-2203 (2011-05-11)
Electrical storm (ES), characterized by recurrent ventricular tachycardia/fibrillation, typically occurs in implantable cardioverter-defibrillator patients and adversely affects prognosis. However, the underlying molecular basis is poorly understood. In the present study, we report a new experimental model featuring repetitive episodes of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A3281-100MG | 04061833267387 |
| A3281-25MG | 04061833360606 |
| A3281-250MG | 04061833267394 |