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A6419

Adenosine 5′-triphosphate disodium salt hydrate

Name: Adenosine 5′-triphosphate disodium salt hydrate
Brand: SIGMA

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

Synonym(s):

ATP disodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O

CAS Number:

34369-07-8

Molecular Weight:

551.14 (anhydrous basis)

UNSPSC Code:

12352207

eCl@ss:

32160414

PubChem Substance ID:

24891086

NACRES:

NA.75

MDL number:

MFCD00150755

Assay:

≥99% (HPLC)

Form:

powder

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biological source

microbial

Quality Level

200

product line

BioReagent

assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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Related Categories

Biochemicals

Biological Buffers

Phosphates

General description

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems. They are released from cells under stress and play a key role in immune response. ATP release from injured neurons and consequent breakdown leads to generation of adenosine. ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain. Elevated ATP levels are indicative of cell damage and inflammation.

Application

Adenosine 5′-triphosphate disodium salt hydrate has been used:

as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites
in inflammasome activation assays in bone marrow derived macrophages
for the stimulation of macrophages
in nucleotide synthesis

Biochem/physiol Actions

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

P₂ purinocepter agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Extracellular ATP and adenosine: the Yin and Yang in immune responses?

Faas MM, et al.

Molecular Aspects of Medicine, 55(5), 9-19 (2017)

Deuterated nucleotides as chemical probes of RNA structure: a detailed protocol for the enzymatic synthesis of a complete set of nucleotides specifically deuterated at ribose carbons

Tullius T, et al.

ScienceOpen Research (2018)

Effect of interleukin-31 on septic shock through regulating inflammasomes and interleukin-1beta

Gu X, et al.

Experimental and Therapeutic Medicine, 16(1), 171-177 (2018)

Adenosine and its receptors as therapeutic targets: an overview

Sachdeva S and Gupta M

Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(3), 245-253 (2013)

MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina.

Nilisha Fernando et al.

Frontiers in cell and developmental biology, 8, 516-516 (2020-07-17)

MicroRNAs (miRNAs) are small, non-coding RNA molecules that have powerful regulatory properties, with the ability to regulate multiple messenger RNAs (mRNAs) and biological pathways. MicroRNA-223-3p (miR-223) is known to be a critical regulator of the innate immune response, and its

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Global Trade Item Number

SKU	GTIN
A6419-5G	04061833382233
A6419-1G	04061835568062
A6419-10G	04061833382226

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