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Merck
CN

AV39170

Sigma-Aldrich

Anti-HIC2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Hypermethylated in cancer 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

66 kDa

species reactivity

rabbit, guinea pig, mouse, horse, rat, dog, human, bovine

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_055909

UniProt accession no.

Q96JB3

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HIC2(23119)

General description

Hypermethylated in cancer 2 (HIC2 or HRG22) is a transcriptional repressor that can self-associate and also interact with HIC1.
Rabbit Anti-HIC2 antibody recognizes human, mouse, rat, bovine, and canine HIC2.

Immunogen

Synthetic peptide directed towards the N terminal region of human HIC2

Application

Rabbit Anti-HIC2 antibody is suitable for western blot applications at a concentration of 2.0 μg/ml.

Biochem/physiol Actions

HIon Channel2 contains 5 C2H2-type zinc fingers and 1 BTB (POZ) domain. It belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily and is a transcriptional repressor.

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Other Notes

Synthetic peptide located within the following region: MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGFLCDVII

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
QC8604

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S Deltour et al.
Biochemical and biophysical research communications, 287(2), 427-434 (2001-09-14)
Database searches identified on chromosome 22q11.2, a region subject to translocations, an homologue of the HIC1 (hypermethylated in cancer) candidate tumor suppressor gene located at 17p13.3. This gene was termed HRG22 for HIC1-related gene on chromosome 22. We have characterized

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