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B3306

Bisindolylmaleimide IV

Name: Bisindolylmaleimide IV
Brand: SIGMA

≥98% (TLC), solid

Synonym(s):

Ro 31-6233

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₃N₃O₂

CAS Number:

119139-23-0

Molecular Weight:

327.34

NACRES:

NA.77

PubChem Substance ID:

24891709

UNSPSC Code:

12352111

MDL number:

MFCD00236432

Assay:

≥98% (TLC)

Form:

solid

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Properties

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (TLC)

form

solid

color

dark red

solubility

DMSO: soluble, methanol: soluble

storage temp.

−20°C

SMILES string

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

Gene Information

human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)

Description

Biochem/physiol Actions

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI. BIMs act as an inhibitor of protein kinase C (PKC). They are derived from staurosporine. BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
B3306-5MG	04061833427668
B3306-1MG	04061833427651