B7559
BW A4C
≥98% (HPLC)
Synonym(s):
N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid
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About This Item
Empirical Formula (Hill Notation):
C17H17NO3
CAS Number:
Molecular Weight:
283.32
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.32
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
79.3-80.1 °C (lit.)
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
InChI key
CEUDWZXMLMKPNN-SOFGYWHQSA-N
Gene Information
human ... ALOX5(240)
rat ... Alox5(25290)
Related Categories
Biochem/physiol Actions
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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S A Yasin et al.
Journal of neuroendocrinology, 6(2), 179-184 (1994-04-01)
Interleukin-1 (IL-1) and interleukin-6 (IL-6) have been reported to stimulate the release of corticotrophin-releasing hormone (CRH) in vitro, the response being antagonized by the cyclo-oxygenase inhibitor, indomethacin. The effects of cytokines on the other major ACTH-releasing hormone, vasopressin (AVP), and
Inhibition of leucotriene-synthesis improves dorsal skin flap survival in the rat.
L Törkvist et al.
Acta physiologica Scandinavica, 154(4), 511-512 (1995-08-01)
S H Oliveira et al.
International archives of allergy and immunology, 111(3), 244-252 (1996-11-01)
Recently we demonstrated that the eosinophil migration into rat peritoneal cavities induced by a large volume of saline is mediated by LTB4 released by the resident macrophages and mast cells. In the present study, we have investigated the involvement of
I D Brodowsky et al.
European journal of pharmacology, 254(1-2), 43-47 (1994-03-11)
Linoleic acid is converted to 8R-hydroperoxylinoleic acid by the soluble 8R-dioxygenase of the fungus Gaeumannomyces graminis. Effects of different lipoxygenase inhibitors on the 8R-dioxygenase were evaluated. Three hydroxamic acid derivatives were investigated. BW A4C (N-(3-phenoxycinnamyl)acetohydroxamic acid) was the most potent
G D Jones et al.
Biochemistry, 35(22), 7197-7203 (1996-06-04)
We have used stopped-flow rapid reaction methods, employing both fluorescence and absorbance monitoring, together with HPLC analysis of the products to study the activation of soybean 15-lipoxygenase by 13(S)-hydroperoxy-9, 11(E,Z)-octadecadienoic acid (13-HPOD). When lipoxygenase is mixed with an equimolar concentration
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