B7559
BW A4C
≥98% (HPLC)
Synonym(s):
N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid
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About This Item
Empirical Formula (Hill Notation):
C17H17NO3
CAS Number:
Molecular Weight:
283.32
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white
mp
79.3-80.1 °C (lit.)
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
CC(=O)N(O)C\C=C\c1cccc(Oc2ccccc2)c1
InChI
1S/C17H17NO3/c1-14(19)18(20)12-6-8-15-7-5-11-17(13-15)21-16-9-3-2-4-10-16/h2-11,13,20H,12H2,1H3/b8-6+
InChI key
CEUDWZXMLMKPNN-SOFGYWHQSA-N
Gene Information
human ... ALOX5(240)
rat ... Alox5(25290)
Biochem/physiol Actions
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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H J Hussey et al.
British journal of cancer, 74(5), 683-687 (1996-09-01)
The potential involvement of lipoxygenase metabolites in the tumour growth stimulatory activity of arachidonic and linoleic acid has been studied using the 5-lipoxygenase inhibitors, BWA4C, BWB70C and Zileuton. In vitro the former two agents were relatively potent inhibitors of growth
C Zuany-Amorim et al.
British journal of pharmacology, 110(2), 917-924 (1993-10-01)
1. The intraperitoneal (i.p.) injection of 1 or 10 micrograms ovalbumin to sensitized Balb/c mice led to an acute histamine release, firstly evidenced 1 min after the challenge and returning to basal levels 30 min thereafter. This phenomenon was unaccompanied
P Montuschi et al.
European journal of pharmacology, 275(1), 31-37 (1995-02-24)
It has been shown previously that both forms of interleukin-1, 1 alpha and 1 beta, produce dose-dependent relaxation of the rat gastric fundus in vitro, accompanied by an increased production and release of eicosanoids. This effect appears to be mediated
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B7559-25MG | 04061832269443 |
| B7559-5MG | 04061833441947 |