Skip to Content
Merck
CN

B8554

Sigma-Aldrich

Anti-Bax antibody, Mouse monoclonal

clone 2D2, purified from hybridoma cell culture

Sign Into View Organizational & Contract Pricing

Select a Size

About This Item

MDL number:
MFCD00282585
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2D2, monoclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa (and possibly a dimer of 42 kDa)

species reactivity

human, bovine

should not react with

rat, mouse

concentration

~2 mg/mL

technique(s)

microarray: suitable
western blot: 1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone

isotype

IgG1

UniProt accession no.

Q07812

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... BAX(581)

Looking for similar products? Visit Product Comparison Guide

General description

Bax is a tumor suppressor that belongs to the Bcl-2 family and modulates cellular apoptosis. Bax is regulated by p53 and increased Bax levels have been associated with cell death stimuli. Alterations in Bax have been linked to several neurological diseases and cancers . Monoclonal Anti-Bax antibody is specific for the epitope within amino acids 3-16 of the human Bax protein. The antibody reacts with Bax in bovines and humans, but not in mice and rats.

Immunogen

synthetic peptide corresponding to amino acids 3-16 of the human Bax sequence, conjugated to KLH.

Application

Monoclonal Anti-Bax antibody is suitable for use in western blot (1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone) and microarray.

Physical form

Solution in phosphate bufered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
048M4889V
096M4839V
052M4851
061M4875
067K4865

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Carter, et al.
Blood Cancer Journal, 13, 57-57 (2023)
K G Wolter et al.
The Journal of cell biology, 139(5), 1281-1292 (1998-01-07)
Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in
Elizabeth S Henson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(3 Pt 1), 845-853 (2006-02-10)
Monoclonal antibodies, such as herceptin and trastuzumab, against the epidermal growth factor receptor ErbB2 (also known as HER2/neu) are an effective therapy for breast cancer patients with overexpression of ErbB2. Herceptin, in combination with standard chemotherapy, such as taxol or
H J Brady et al.
The international journal of biochemistry & cell biology, 30(6), 647-650 (1998-08-08)
Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell death. The Bax protein shares highly conserved domains with Bcl-2, some of which are required for the formation of Bax-Bcl-2 heterodimers. Bax expression is elevated
Bing Z Carter et al.
Haematologica, Online ahead of print (2020-12-24)
MCL-1 and BCL-2 are both frequently overexpressed in acute myeloid leukemia and critical for the survival of acute myeloid leukemia cells and acute myeloid leukemia stem cells. MCL-1 is a key factor in venetoclax resistance. Using genetic and pharmacological approaches
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service