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Merck
CN

B9054

Sigma-Aldrich

Anti-Bax antibody, Mouse monoclonal

2 mg/mL, clone 5B7, purified immunoglobulin, buffered aqueous solution

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About This Item

MDL number:
MFCD00282585
UNSPSC Code:
12352203

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5B7, monoclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa (and possibly a dimer of 42 kDa)

species reactivity

mouse

should not react with

rat, human

concentration

2 mg/mL

technique(s)

immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1-5 μg/mL using mouse fibroblast 3T3 cell extract

isotype

IgG1

UniProt accession no.

Q07813

shipped in

dry ice

storage temp.

−20°C

Gene Information

mouse ... Bax(12028)

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Immunogen

synthetic peptide corresponding to amino acids 3-16 of the mouse Bax sequence, conjugated to KLH

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

The epitope recognized by the antibody resides within amino acids 3-16 of the mouse Bax protein.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
030K4870

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Kate D Sutherland et al.
The EMBO journal, 25(24), 5805-5815 (2006-12-02)
Suppressor of cytokine signalling (SOCS) proteins are critical attenuators of cytokine-mediated signalling in diverse tissues. To determine the importance of Socs3 in mammary development, we generated mice in which Socs3 was deleted in mammary epithelial cells. No overt phenotype was
Y T Hsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(8), 3668-3672 (1997-04-15)
Bcl-2, Bcl-X(L), and Bax are members of the Bcl-2 family that play key roles in the regulation of apoptosis. These proteins are believed to be membrane bound and their ability to undergo both homodimerization and heterodimerization has been proposed to
J-P Upton et al.
Cell death and differentiation, 14(5), 932-942 (2007-02-03)
The Bcl-2 protein Bax normally resides in the cytosol, but during apoptosis it translocates to mitochondria where it is responsible for releasing apoptogenic factors. Using anoikis as a model, we have shown that Bax translocation does not commit cells to
T W Owens et al.
Cell death and differentiation, 16(11), 1551-1562 (2009-08-08)
Most cells undergo apoptosis through the intrinsic pathway. This is dependent on mitochondrial outer membrane permeabilisation (MOMP), which is mediated by the pro-apoptotic Bcl-2 family proteins, Bax and Bak. During apoptosis, Bax translocates from the cytosol to the outer mitochondrial
Leilei Zhang et al.
The Journal of pharmacology and experimental therapeutics, 374(2), 308-318 (2020-06-18)
ME-344 is a second-generation cytotoxic isoflavone with anticancer activity promulgated through interference with mitochondrial functions. Using a click chemistry version of the drug together with affinity-enriched mass spectrometry, voltage-dependent anion channels (VDACs) 1 and 2 were identified as drug targets.
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