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Merck
CN

C0330

Ciprofibrate

Synonym(s):

2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H14Cl2O3
CAS Number:
52214-84-3
Molecular Weight:
289.15
NACRES:
NA.77
PubChem Substance ID:
24278288
UNSPSC Code:
41116107
EC Number:
257-744-6
MDL number:
MFCD00467135

Key Documents

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InChI key

KPSRODZRAIWAKH-UHFFFAOYSA-N

InChI

1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

SMILES string

CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O

form

powder

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PPARA(5465)

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Biochem/physiol Actions

Peroxisome proliferator-activated receptor α (PPARα) agonist

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H350

Hazard Classifications

Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
019M4057V
13181125
098M4064V
13160319
068M4118V

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P Passilly et al.
Biochemical pharmacology, 58(6), 1001-1008 (1999-10-06)
The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could
Fabiana D Mendes et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2361-2368 (2011-07-19)
A rapid, sensitive and specific method for quantifying ciprofibrate in human plasma using bezafibrate as the internal standard (IS) is described. The sample was acidified prior extraction with formic acid (88%). The analyte and the IS were extracted from plasma
Fatemeh Sharifpanah et al.
Stem cells (Dayton, Ohio), 26(1), 64-71 (2007-10-24)
Peroxisome proliferator-activated receptors (PPARalpha, -beta and -gamma) are nuclear receptors involved in transcriptional regulation of lipid and energy metabolism. Since the energy demand increases when cardiac progenitor cells are developing rhythmic contractile activity, PPAR activation may play a critical role
Sung Hun Kim et al.
Toxicology and applied pharmacology, 215(2), 198-207 (2006-04-18)
The present study was undertaken to determine the role of the mitogen-activated protein kinase (MAPK) subfamilies in cell death induced by PPARgamma agonists in osteoblastic cells. Ciglitazone and troglitazone, PPARgamma agonists, resulted in a concentration- and time-dependent cell death, which
Alessandro Antonelli et al.
Experimental cell research, 317(11), 1527-1533 (2011-05-14)
Until now, no data are present about the effect of peroxisome proliferator-activated receptor (PPAR)α activation on the prototype Th1 [chemokine (C-X-C motif) ligand (CXCL)10] (CXCL10) and Th2 [chemokine (C-C motif) ligand 2] (CCL2) chemokines secretion in thyroid cells. The role
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