C7124
Cryptolepine hydrate
≥98% (HPLC)
Synonym(s):
5-Methyl-5H-quindoline hydrate
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About This Item
Empirical Formula (Hill Notation):
C16H12N2 · xH2O
CAS Number:
Molecular Weight:
232.28 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
AOTFRBDOIUZYCT-UHFFFAOYSA-N
SMILES string
O.Cn1c2ccccc2cc3nc4ccccc4c13
InChI
1S/C16H12N2.H2O/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14;/h2-10H,1H3;1H2
assay
≥98% (HPLC)
form
powder
color
purple
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Cryptolepine hydrate is a cytoxic, anti-cancer, antimalarial agent
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yumin Zhang et al.
Frontiers in cellular and infection microbiology, 11, 624745-624745 (2021-03-26)
Human babesiosis is a CDC reportable disease in the United States and is recognized as an emerging health risk in multiple parts of the world. The current treatment for human babesiosis is suboptimal due to treatment failures and unwanted side
Yu-Jing Lu et al.
Chemical communications (Cambridge, England), 47(17), 4971-4973 (2011-03-25)
A new switch-on fluorescent probe containing the natural product cryptolepine analogue benzofuroquinolinium moiety (binding scaffold) and a benzothiazole moiety (signalling unit) shows a remarkable fluorescence enhancement selective for the G-quadruplex nucleic acid structure. Binding studies revealed that the highly selective
Louise R Whittell et al.
Bioorganic & medicinal chemistry, 19(24), 7519-7525 (2011-11-08)
A series of mono- and di-substituted analogues of isocryptolepine have been synthesized and evaluated for in vitro antimalarial activity against chloroquine sensitive (3D7) and resistant (W2mef) Plasmodium falciparum and for cytotoxicity (3T3 cells). Di-halogenated compounds were the most potent derivatives
Rajendran C Gopalan et al.
Toxicology letters, 207(3), 322-325 (2011-09-29)
Malaria is a mosquito-borne infectious disease caused by the genus Plasmodium. It causes one million deaths per year in African children under the age of 5 years. There is an increasing development of resistance of malarial parasites to chloroquine and
João Lavrado et al.
Bioorganic & medicinal chemistry letters, 22(19), 6256-6260 (2012-08-29)
Cryptolepine derivatives containing alkyldiamine side-chains, 2, with potent inhibitory activity against Trypanosoma brucei brucei are reported. Compounds 2 showed improved activity and selectivity to T. b. brucei when compared to the lead compound. The most selective compound, 2k, presents a
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