D9446
L-DOPS
≥98% (HPLC)
Synonym(s):
Droxidopa, L-threo 3,4-Dihydroxyphenylserine
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About This Item
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥3 mg/mL
storage temp.
−20°C
SMILES string
N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(O)=O
InChI
1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChI key
QXWYKJLNLSIPIN-JGVFFNPUSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
General description
Application
Biochem/physiol Actions
Features and Benefits
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate and FLA-63. Inhibition of the enzyme effectively reduces tissue norepinephrine levels.
多巴胺-β-羟化酶位于去甲肾上腺素神经元的胺存储囊泡内。多巴胺通过主动运输而从细胞质转运到囊泡中。由于该酶是一种含铜的蛋白质，因此其活性会被铜螯合剂，如二乙基二硫代氨基甲酸酯和FLA-63所抑制。对该酶的抑制可有效降低组织去甲肾上腺素的水平。
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9446-25MG | 04061833590768 |
| D9446-5MG | 04061833218471 |