biological source
synthetic
Quality Level
Assay
95.0-105.0%
form
powder
color
white to off-white
pKa
9.8
mp
236-251 °C (lit.)
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
enzyme | inhibits
originator
Teva
SMILES string
COc1cc(cc(OC)c1O)[C@H]2[C@@H]3[C@H](COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
InChI
1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key
VJJPUSNTGOMMGY-MRVIYFEKSA-N
Gene Information
human ... ABCB1(5243) , CYP3A4(1576) , TOP2A(7153) , TOP2B(7155)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Top2a(360243)
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General description
Application
- to prepare drug stock solution in dimethyl sulfoxide (DMSO) and also to profile and compare the sensitivity of DT40 mutant cells
- to incubate cells for cell viability assay
- to treat neuro-2A cells to induce programmed cell death
Biochem/physiol Actions
Features and Benefits
Packaging
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Repr. 2
Storage Class Code
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
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Articles
Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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