F1553
S-(+)-Fluoxetine hydrochloride
≥98% (HPLC), serotonin reuptake inhibitor, solid
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About This Item
Empirical Formula (Hill Notation):
C17H18NOF3 · HCl
CAS Number:
Molecular Weight:
345.79
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D +14 to +19°, c = 1 in chloroform-d
storage condition
desiccated
color
white
solubility
H2O: soluble ≥20 mg/mL
originator
Eli Lilly
storage temp.
room temp
SMILES string
Cl.CNCC[C@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2
InChI
1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m0./s1
InChI key
GIYXAJPCNFJEHY-NTISSMGPSA-N
Gene Information
Related Categories
General description
Fluoxetine hydrochloride or fluoxetine hcl is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac®.
Biochem/physiol Actions
Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Selective serotonin reuptake inhibitor.
Features and Benefits
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Prozac is a registered trademark of Eli Lilly and Co.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S Hasebe et al.
British journal of pharmacology, 174(4), 314-327 (2016-12-18)
Prefrontal dopamine release by the combined activation of 5-HT Male mice were treated with picrotoxin to decrease GABA Picrotoxin caused an anxiogenic effect on three behavioural tests, but it did not affect the immobility time in the forced swim test.
David T Wong et al.
Nature reviews. Drug discovery, 4(9), 764-774 (2005-08-27)
In the early 1970s, evidence of the role of serotonin (5-hydroxytryptamine or 5-HT) in depression began to emerge and the hypothesis that enhancing 5-HT neurotransmission would be a viable mechanism to mediate antidepressant response was put forward. On the basis
Xin-Xian Ye et al.
Nuclear medicine and biology, 31(5), 557-562 (2004-06-29)
A radiopharmaceutical, (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([(123)I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F1553-25MG | 04061832090795 |
| F1553-5MG | 04061832090801 |
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