F1678
R-(−)-Fluoxetine hydrochloride
>98% (HPLC), solid
Synonym(s):
(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H18NOF3 · HCl
CAS Number:
Molecular Weight:
345.79
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
>98% (HPLC)
form
solid
storage condition
desiccated
color
white
solubility
H2O: soluble >10 mg/mL
originator
Eli Lilly
SMILES string
Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2
InChI
1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1
InChI key
GIYXAJPCNFJEHY-PKLMIRHRSA-N
Gene Information
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Related Categories
Application
R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:
- to study its effects on the embryoid body (EB) morphogenesis
- in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
- to study its effects as an endocrine disruption inducer in Pimephales promelas
Biochem/physiol Actions
Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.
Selective serotonin reuptake inhibitor.
Features and Benefits
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 165(2), 372-388 (2018-06-13)
Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by
Bibiana Scelfo et al.
Toxicology, 299(2-3), 172-183 (2012-06-06)
Cortical neurons grown on multielectrode array (MEA) chips have been shown to be a valuable alternative method to study electrophysiological properties of the central nervous system neurons and to perform functional toxicological screening. Here we studied the effects of binary
Maria Gonzalez-Rey et al.
Environmental pollution (Barking, Essex : 1987), 173, 200-209 (2012-12-04)
Fluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac(®) is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Chromatograms
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