F6300
Flumazenil
>99% (HPLC), solid, benzodiazepine receptor antagonist
Synonym(s):
Ro 15-1788, Ro15-1788
Sign Into View Organizational & Contract Pricing
About This Item
Empirical Formula (Hill Notation):
C15H14FN3O3
CAS Number:
Molecular Weight:
303.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Flumazenil, >99% (HPLC), solid
Quality Level
Assay
>99% (HPLC)
form
solid
color
white
originator
Roche
storage temp.
2-8°C
SMILES string
CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23
InChI
1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key
OFBIFZUFASYYRE-UHFFFAOYSA-N
Gene Information
Looking for similar products? Visit Product Comparison Guide
Related Categories
General description
Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.
Biochem/physiol Actions
Highly specific benzodiazepine receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Donna L Seger
Journal of toxicology. Clinical toxicology, 42(2), 209-216 (2004-06-25)
Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined
A A Weinbroum et al.
European journal of anaesthesiology, 18(12), 789-797 (2001-12-12)
Midazolam may occasionally precipitate hostility and violence instead of tranquility. We characterized these episodes, their rate of occurrence, the potential paradoxical responders and possible predisposing circumstances among patients undergoing lower body surgery under spinal or epidural anaesthesia and midazolam sedation.
Effect of flumazenil on memory retrieval determined by trial-to-criteria inhibitory avoidance method in mice
Raut SB, et al.
Journal of Pharmacology & Pharmacotherapeutics, 7(1), 24-24 (2016)
N W Duncan et al.
Neuroscience, 235, 226-231 (2013-02-06)
Voxel based morphometry (VBM) is a widely used technique for studying the structure of the brain. Direct comparisons between the results obtained using VBM and the underlying histology are limited, however. To circumvent the problems inherent in comparing VBM data
A A Weinbroum et al.
Drug safety, 17(3), 181-196 (1997-11-05)
The worldwide expansion in the use of benzodiazepines has led to their frequent, and often inappropriate, use and to increase in their involvement in self-induced poisoning and iatrogenic overdosing. Flumazenil is a specific and competitive antagonist at the central benzodiazepine
Articles
DISCOVER Bioactive Small Molecules for Neuroscience
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service