F8053
Anti-FADD antibody, Mouse monoclonal
clone FD19, purified from hybridoma cell culture
Synonym(s):
Anti-Fas Associated Death Domain
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About This Item
Conjugate:
unconjugated
Clone:
FD19, monoclonal
Application:
ARR, ELISA (i), IP, WB
Citations:
11
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
FD19, monoclonal
form
buffered aqueous solution
mol wt
antigen ~28 kDa
species reactivity
human
concentration
~2 mg/mL
technique(s)
immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using total cell extracts of A431 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FADD(8772)
General description
Anti-FADD antibody, Mouse monoclonal (mouse IgG1) is derived from the FD19 hybridoma produced by the fusion of murine myeloma cells (NS1) and splenocytes from mouse immunized with purified recombinant human FADD.
Immunogen
purified recombinant human FADD.
Application
Anti-FADD antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunoprecipitation
- enzyme-linked immunosorbent assay (ELISA)
Biochem/physiol Actions
FADD (Fas Associated Death Domain) is associated with various non-apoptotic cellular pathways such as regulation of cell cycle machinery in T lymphocytes connected to the phosphorylation state of FADD and to the FasL/TRAIL-induced transcriptional activation of c-fos protooncogene. It also interacts with the hepatitis C virus core protein in the HEK-293 cell line.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs
Huang Y, et al.
International Journal of Oncology, 49(1), 153-163 (2016)
A novel naphthyridine derivative, 3u, induces necroptosis at low concentrations and apoptosis at high concentrations in human melanoma A375 cells
Kong Q, et al.
International Journal of Molecular Sciences, 19(10), 2975-2975 (2018)
Ying Huang et al.
International journal of oncology, 49(1), 153-163 (2016-05-24)
The discovery of the TRAIL protein and its death receptors DR4/5 changed the horizon of cancer research because TRAIL specifically kills cancer cells. However, the validity of TRAIL-based cancer therapies has yet to be established, as most cancer cells are
Qinghong Kong et al.
International journal of molecular sciences, 19(10) (2018-10-03)
Naphthyridine derivatives are a widely-used class of heterocycles due to their pharmacological activities. A novel compound (10-Methoxy-1,2,3,4-tetrahydrobenzo(g)(1,3) diazepino(1,2-a)-(1,8)naphthyridin-6-yl)(phenyl) methanone (named 3u), showed good anticancer activity in the human malignant melanoma cell line A375 via Thiazolyl Blue Tetrazolium Bromide (MTT) assay.
J Zhang et al.
The Journal of biological chemistry, 276(32), 29815-29818 (2001-06-08)
FADD is an adapter protein that was originally isolated as a transducer of apoptotic signals for death domain-containing receptors. However, FADD-deficient mice are embryonic lethal and FADD(-/-) T cells developed from FADD(-/-) embryonic stem cells in the RAG-1(-/-) hosts lack
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8053-200UL | 04061838105363 |
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