G1420
Anti-Glutamate Receptor 1, Metabotropic antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-mGluR1
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL using human brain, neurons
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... GRM1(2911)
mouse ... Grm1(14816)
rat ... Grm1(24414)
Immunogen
synthetic peptide corresponding to the C-terminal of human metabotropic glutamate receptor 1, conjugated to KLH. The immunizing peptide has 88% homology with the rat and mouse gene.
Application
Anti-Glutamate Receptor 1, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL using human brain, neurons.
Biochem/physiol Actions
Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. Group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of Group I appear to have a neuroprotective effect.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Instructions
W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells.
Thomas Knöpfel et al.
Cerebellum (London, England), 1(1), 19-26 (2003-07-26)
Metabotropic glutamate receptors (mGluRs) are a family of proteins that have seven transmembrane segments and that couple to G proteins. They differ from ionotropic glutamate receptors in that they do not form ion channels but instead affect intracellular chemical messenger
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to