CN
GRM1
glutamate receptor, metabotropic 1
Synonyms:
GPRC1A, MGLU1, MGLUR1, SCAR13
Species:
Human GRM1 (2911), Mouse Grm1 (14816), Rat Grm1 (24414), domestic guinea pig Grm1 (100730891), naked mole-rat Grm1 (101712477), Zebrafish grm1 (100150246), chicken GRM1 (421614), dog GRM1 (484024), Horse GRM1 (100060603), domestic cat GRM1 (101094104) ...More
UniProtKB ID:
Gene ID:
- Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
- Mouse(14816) glutamate receptor, metabotropic 1
- Rat(24414) glutamate receptor, metabotropic 1
- domestic guinea pig(100730891) glutamate receptor, metabotropic 1
- naked mole-rat(101712477) glutamate receptor, metabotropic 1
- Zebrafish(100150246) glutamate receptor, metabotropic 1
- chicken(421614) glutamate receptor, metabotropic 1
- dog(484024) glutamate receptor, metabotropic 1
- Horse(100060603) glutamate receptor, metabotropic 1
- domestic cat(101094104) glutamate receptor, metabotropic 1
- cow(540485) glutamate receptor, metabotropic 1
- Domestic Rabbit(100356201) glutamate receptor, metabotropic 1
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Small Molecule - Agonist
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-Glutamate antibody produced in mouse, clone GLU-4, ascites fluid,
Species Reactivity
wide range
Application
ELISA
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-GRM1 antibody produced in mouse, clone 1F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human