synthetic peptide corresponding to the N-terminal extracellular domain of human metabotropic glutamate receptor 3, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Anti-Glutamate Receptor 3, Metabotropic antibody produced in rabbit is suitable for:

• western blot analysis of mouse somatosensory cortex to examine the connexin 36 (Cx36) protein expression and electrotonic coupling incidence.
• western blot analysis of rat hypothalamus to study the Cx36 expression.
• immunocytochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 38μg/mL using human brain, neurons and glia.

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. Group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.

Solution in phosphate buffered saline, containing 0.1% sodium azide.

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