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G3295

GW0742

Name: GW0742
Brand: SIGMA

≥98% (HPLC), selective PPARδ agonist, powder

Synonym(s):

4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₇F₄NO₃S₂

CAS Number:

317318-84-6

Molecular Weight:

471.49

UNSPSC Code:

12352200

PubChem Substance ID:

24895123

NACRES:

NA.77

MDL number:

MFCD07369423

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

GW0742, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

mp

134.5-135.5 °C

solubility

DMSO: >5 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Cc1cc(SCc2sc(nc2C)-c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(O)=O

InChI

1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)

InChI key

HWVNEWGKWRGSRK-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465), PPARD(5467), PPARG(5468)

Related Categories

Bioactive Small Molecule Agonists

Bioactive Small Molecules

Biochem/physiol Actions

GW0742 is a highly selective PPARδ agonist.

GW0742 is a highly selective PPARδ agonist. EC₅₀= 1 nM vs 1 μM and 2 μM for PPARα and PPARγ, respectively.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.

Amar Bahadur Singh et al.

The Journal of biological chemistry, 292(3), 884-897 (2016-12-04)

Peroxisome proliferator-activated receptor δ (PPARδ) regulates many genes involved in lipid metabolism. Hepatic lysophosphatidylcholine acyltransferase 3 (LPCAT3) has critical functions in triglycerides transport and endoplasmic reticulum stress response due to its unique ability to catalyze the incorporation of polyunsaturated fatty

PPAR-δ Agonist With Mesenchymal Stem Cells Induces Type II Collagen-Producing Chondrocytes in Human Arthritic Synovial Fluid.

Bruce E Heck et al.

Cell transplantation, 26(8), 1405-1417 (2017-09-14)

Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by 2030. Thus

The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.

Megan E Capozzi et al.

Experimental eye research, 190, 107885-107885 (2019-11-24)

Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids. Free fatty acids may serve as an initiator of inflammatory cytokine release from Müller cells, and the resulting

Lipid-body containing interstitial cells (lipofibroblasts) in the lungs of various mouse strains.

Luka Opitz et al.

Journal of anatomy, 231(6), 970-977 (2017-08-09)

Pulmonary alveolar septa are thought to contain at least two types of fibroblasts that are termed myofibroblasts and lipofibroblasts based on their morphological characteristics. Lipofibroblasts possess cytoplasmic lipid inclusions (lipid bodies or droplets) and are involved in several important functions

Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus.

Haruyo Yagi et al.

Stem cell research & therapy, 11(1), 293-293 (2020-07-19)

There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop more effective and less invasive forms of antimicrobial

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Global Trade Item Number

SKU	GTIN
G3295-1MG	04061833629871
G3295-5MG	04061832954356

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