I1658
Anti-phospho-Insulin Receptor Substrate-1 (pTyr1179) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-phospho-IRS-1 (pTyr1179)
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, rat, mouse
technique(s)
western blot: 0.1-1.0 μg/mL using stimulated CHO cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IRS1(3667)
mouse ... Irs1(16367)
rat ... Irs1(25467)
General description
Insulin receptor substrate-1 (IRS-1) is among the four IRS proteins (IRS-1-IRS-4) that mediate signalling by insulin receptor (IR) and insulin-like growth factor (IGF) receptor. IRS-1 has a pleckstrin homology domain and a phosphotyrosine-binding domain. Phosphorylation of the Tyr1179 residue in the SH-1 negatively regulates insulin. IRS-1 has the abililty to translocate to the nucleus, the mechanism of which is not very clear. Estrogen receptors (ER) α and β have a strong affinity to IRS-1, an important interaction in breast cancers and medulloblastomas. The expression of IRS-1 in prostate cancer is associated with lower tumor cell invasiveness. Along with ER α, IRS-1 also modulates transcriptional activity involved in the development of breast and prostate cancer. The signalling pathway involving IGF-IR-IRS-1 in cells expressing JCV T-antigen has been reported to affect the proliferation, survival and DNA repair in the cells
Anti-phospho-IRS-1 (pTyr1179) specifically recognizes human IRS-1 (pTyr1179). It may react with mouse (100% homology) and rat (93% homology) IRS-1.
Anti-phospho-IRS-1 (pTyr1179) specifically recognizes human IRS-1 (pTyr1179). It may react with mouse (100% homology) and rat (93% homology) IRS-1.
Immunogen
synthetic phosphopeptide derived from the region of mouse insulin receptor substrate-1 that is phosphorylated on tyrosine 1173 (corresponding to tyrosine 1179 of the human sequence).
Application
Anti-phospho-IRS-1 (pTyr1179) antibody may be used for detection by immunoblotting, in stimulated CHO cell line, at a working concentration of 0.1 to 1.0 μg/ml.
Physical form
Solution in phosphate buffered saline, pH 7.3, containing 1 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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W Ogawa et al.
Molecular and cellular biochemistry, 182(1-2), 13-22 (1998-06-03)
Insulin elicits its divergent metabolic and mitogenic effects by binding to its specific receptor, which belongs to the family of receptor tyrosine kinases. The activated insulin receptor phosphorylates the intracellular substrate IRS-1, which then binds various signalling molecules that contain
Catia Morelli et al.
Oncogene, 23(45), 7517-7526 (2004-08-20)
Insulin receptor substrate 1 (IRS-1) is a major signaling molecule activated by the insulin and insulin-like growth factor I receptors. Recent data obtained in different cell models suggested that in addition to its conventional role as a cytoplasmic signal transducer
X J Sun et al.
The Journal of biological chemistry, 267(31), 22662-22672 (1992-11-15)
IRS-1 is a major insulin receptor substrate which may play an important role in insulin signal transmission. The mRNA for IRS-1 in rat cells and tissues is about 9.5 kilobases (kb). Rat liver IRS-1 was stably expressed in Chinese hamster
M G Myers et al.
Endocrinology, 132(4), 1421-1430 (1993-04-01)
IRS-1 is a unique cytosolic protein that becomes tyrosine phosphorylated during insulin stimulation of intact cells and immediately associates with the phosphatidylinositol 3'-kinase (PtdIns 3'-kinase). The insulin-like growth factor-I (IGF-I) receptor also mediated the tyrosine phosphorylation of IRS-1 and increased
Krzysztof Reiss et al.
Journal of cellular physiology, 227(8), 2992-3000 (2012-03-29)
The family of insulin receptor substrates (IRS) consists of four proteins (IRS-1-IRS-4), which were initially characterized as typical cytosolic adaptor proteins involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling. The first cloned and characterized member
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