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Merck
CN

I2516

Isocitric Dehydrogenase (NADP) from porcine heart

lyophilized powder, 20-60 units/mg protein (biuret)

Synonym(s):

threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH

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About This Item

CAS Number:
UNSPSC Code:
12352204
EC Number:
232-835-3
MDL number:
EC Number:
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form

lyophilized powder

specific activity

20-60 units/mg protein (biuret)

composition

Protein, ~20%

storage temp.

−20°C

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Physical form

Lyophilized powder containing sodium citrate and manganous sulfate

Analysis Note

Highly purified
Essentially free of aconitase activity.

Other Notes

One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Lynn J Poole Perry et al.
American journal of ophthalmology, 155(3), 593-608 (2012-12-12)
To evaluate the cellular nature of and diagnostic terminology used in connection with acquired retinal "vasoproliferative tumors." Retrospective clinicopathologic study. Clinical records and microscopic slides of 4 enucleated globes were reviewed. Special stains and immunohistochemical probes for CD31, CD34, p53
O Zalatimo et al.
Advances in experimental medicine and biology, 779, 267-289 (2013-01-05)
Primary brain tumors constitute a substantial public health problem with 66,290 cases diagnosed in the US in 2012, and 13,700 deaths recorded. With discovery of genetic factors associated with specific brain tumor subtypes, the goal of therapy is changing from
Rithvik Vinekar et al.
BMC bioinformatics, 13 Suppl 17, S2-S2 (2013-01-11)
Isocitrate Dehydrogenases (IDHs) are important enzymes present in all living cells. Three subfamilies of functionally dimeric IDHs (subfamilies I, II, III) are known. Subfamily I are well-studied bacterial IDHs, like that of Escherischia coli. Subfamily II has predominantly eukaryotic members
Jay P Patel et al.
Hematology. American Society of Hematology. Education Program, 2012, 28-34 (2012-12-13)
Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease alleles in AML, recent genome-wide
Omar Abdel-Wahab et al.
Hematology. American Society of Hematology. Education Program, 2012, 56-64 (2012-12-13)
The myelodysplastic syndromes (MDS) are a clinically and cytogenetically heterogeneous group of clonal diseases characterized by ineffective hematopoiesis, peripheral blood cytopenias, and an increased risk of progression to acute myeloid leukemia. The precise molecular mechanisms behind the development of MDS

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