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Merck
CN

L144

Mevinolin from Aspergillus sp.

powder

Synonym(s):

2-Methyl-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid, 6-α-Methylcompactin, Lovastatin, Monacolin K

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About This Item

Empirical Formula (Hill Notation):
C24H36O5
CAS Number:
75330-75-5
Molecular Weight:
404.54
UNSPSC Code:
12352204
PubChem Substance ID:
329817390
MDL number:
MFCD00072164

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InChI

1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

SMILES string

[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC

InChI key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

form

powder

color

off-white

solubility

DMSO: >10 mg/mL, ethanol: 16 mg/mL, H2O: insoluble

storage temp.

2-8°C

Gene Information

human ... HMGCR(3156)

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Aleksi Tornio et al.
Pharmacogenetics and genomics, 25(8), 382-387 (2015-05-29)
Organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1 gene) is a hepatic uptake transporter, and its genetic variability is associated with pharmacokinetics and muscle toxicity risk of simvastatin. We examined the possible effects of variations in the SLCO1B1 gene
Paul Curnow et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(3), 773-778 (2009-01-15)
Biology relies on the precise self-assembly of its molecular components. Generic principles of protein folding have emerged from extensive studies on small, water-soluble proteins, but it is unclear how these ideas are translated into more complex situations. In particular, the
Patricia A Reis et al.
PLoS pathogens, 8(12), e1003099-e1003099 (2013-01-10)
Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection in children and non-immune adults. Previous work has documented a persistent cognitive impairment in children who survive an episode of CM that is mimicked in animal models of
Emily K Osterweil et al.
Neuron, 77(2), 243-250 (2013-01-29)
Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct
Chia-Hao Chen et al.
International journal of pharmaceutics, 444(1-2), 18-24 (2013-01-29)
Lovastatin, categorized as a class II compound according to the Biopharmaceutics Classification System, is mainly responsible for the blood cholesterol lowering effect of red yeast rice (RYR). The aim of this study was to compare the dissolution rate, physical state
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