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Merck
CN

L3669

LPK-26

≥98% (HPLC), powder

Synonym(s):

2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(2-isopropyl)-2-(1-(3-pyrrolinyl))ethyl]acetamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H24Cl2N2O · HCl
CAS Number:
492451-07-7
Molecular Weight:
391.76
NACRES:
NA.77
PubChem Substance ID:
329817406
UNSPSC Code:
12352200
MDL number:
MFCD11114388

Key Documents

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InChI key

WOOCHAFXTYNYQE-UNTBIKODSA-N

SMILES string

Cl.CC(C)[C@@H](CN1CC=CC1)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2

InChI

1S/C18H24Cl2N2O.ClH/c1-13(2)17(12-22-8-4-5-9-22)21(3)18(23)11-14-6-7-15(19)16(20)10-14;/h4-7,10,13,17H,8-9,11-12H2,1-3H3;1H/t17-;/m1./s1

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

LPK-26 is a potent, selective kappa opioid receptor agonist and an antinociceptive, devoid physical dependence properties.
LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). It has extremely high kappa affinity (0.64 nM) and low mu and delta receptor affnities (1170 and 10,000nM). LPK-26 produces an antinocicpetive effect with much higher potency in vivo than morphine or U50488. LPK-26 does not produce physical dependence in mice, but it does suppress naloxone-induced behavioral effects in mice treated with morphine.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
078K4618V
078K4618

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Articles

Opioid Receptors

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