L7149
L-Lobeline
Synonym(s):
2-(6-[2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl)-1-phenylethanone
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About This Item
Empirical Formula (Hill Notation):
C22H27NO2
CAS Number:
Molecular Weight:
337.46
UNSPSC Code:
12352200
EC Number:
202-012-3
InChI
1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
InChI key
MXYUKLILVYORSK-HBMCJLEFSA-N
Biochem/physiol Actions
Agonist at high-affinity neuronal nicotinic acetylcholine receptors; respiratory stimulant. Inhibits synaptosomal accumulation of dopamine by interaction with the tetrabenazine binding site of the vesicular monoamine transporter (VMAT2). Blocks amphetamine-induced dopamine release.
Regulatory Information
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Ryan M Joseph et al.
Genetics, 192(2), 521-532 (2012-07-17)
Understanding sensory systems that perceive environmental inputs and neural circuits that select appropriate motor outputs is essential for studying how organisms modulate behavior and make decisions necessary for survival. Drosophila melanogaster oviposition is one such important behavior, in which females
J J Dimatelis et al.
Metabolic brain disease, 27(3), 351-361 (2012-03-07)
Exposure to early life stress has been suggested to increase an individual's vulnerability to methamphetamine (MA) dependence. Although there is no cure for drug dependence, the opioid and vesicular monoamine transporter 2 (VMAT2) systems may be useful targets for treatment
Ansel T Hillmer et al.
Journal of neuroscience methods, 214(2), 163-169 (2013-02-02)
Lobeline is a potential smoking cessation drug with affinity for the α4β2 nicotinic acetylcholine receptor and may inhibit the blood-brain barrier (BBB) amine transporter. The goal of this work was to use PET imaging to evaluate the effects of lobeline