M8569
Anti-MAFF (N-terminal) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-v-maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Family, ProteinF
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 18 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): 4-8 μL using A431 cell line, western blot: 1:4,000-1:8,000 using whole extracts of the A431 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAFF(23764)
mouse ... Maff(17133)
rat ... Maff(366960)
General description
Anti-MAFF (N-terminal) is developed in rabbit using a synthetic peptide corresponding to amino acids of human MAFF, conjugated to keyhole limpet hemocyanin (KLH) via a C-terminal added cysteine residue, as immunogen. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Human MAF bZIP transcription factor F (MAFF) encodes a 164 amino acids protein. It lacks an N-terminal transactivating domain.
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) is a transcription factor which does not have a transactivation domain but possesses a leucine-zipper.
Immunogen
synthetic peptide corresponding to amino acids 2-17 of human MAFF, conjugated to KLH via a C-terminal added cysteine residue. The mouse and rat sequences differ from the human by one and two amino acids, respectively. Seven amino acids are identical in MaFG in the C-terminal region of the peptide.
Application
Anti-MAFF (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
The three small Maf proteins participates in development, differentiation, hematopoiesis and stress response.
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F (MAFF) has been shown to interact with other transcription factors and it associates with certain regulatory sequences in the gene encoding the oxytocin receptor.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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The Minimal Transactivation Domain of the Basic Motif-Leucine Zipper Transcription Factor NRL Interacts with TATA-binding Protein
Friedman JS, et al.
The Journal of Biological Chemistry, 279(45), 47233-47241 (2004)
Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators
Moran JA, et al.
The Biochemical Journal, 361(2), 371-377 (2002)
O Johnsen et al.
Nucleic acids research, 24(21), 4289-4297 (1996-11-01)
The human TCF11 gene encodes a ubiquitously expressed bZIP transcription factor of the cap n' collar (CNC) domain family. It has a high sequence similarity to the erythroid-specific bZIP factor p45 NF-E2 in the CNC domain, which is involved in
Xiaoxia Ye et al.
Archives of biochemistry and biophysics, 449(1-2), 87-93 (2006-03-22)
The human transcription factor MafF (hMafF) lacks a transactivation domain, it contains a heptad-leucine repeat motif (viz., Leu-zipper) that may mediate protein-protein interactions to regulate transcriptional activities. A protein with a coiled-coil domain encoded by a novel human gene (GenBank
Wael Massrieh et al.
Biology of reproduction, 74(4), 699-705 (2005-12-24)
The MAF (proto-)oncogene family of basic-leucine zipper transcription factors plays crucial roles in the control of mammalian gene expression and development. Here we analyzed the regulation of the human MAFF gene, coding for a small MAF transcription factor, in uterine
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