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Merck
CN

P1922

Sigma-Aldrich

Monoclonal Anti-Progesterone antibody produced in rat

clone 2H4, tissue culture supernatant

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rat

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

2H4, monoclonal

technique(s)

indirect ELISA: 1:1000 - 1:2000 (using Progesterone-BSA for coating.)
radioimmunoassay: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Related Categories

General description

Progesterone or P4 (pregn-4-ene-3,20-dione) is a female steroid hormone that belongs to the hormones class, progestogens. It is produced by majorly by ovaries, adrenal glands and placenta of humans and other species. Progesterone derived from placenta and corpus luteum is required for the maintenance of pregnancy. Progesterone inhibits the T cell mediated immune response involved in tissue rejection. The progesterone levels in females are low before ovulation and are elevated during the luteal phase. Monoclonal Anti-Progesterone antibody is IgG1 isotype purified from rat cell culture supernatant.

Immunogen

progesterone-7-BSA.

Application

The antibody may be used in various immunochemical techniques including ELISA, radioimmunoassay AND RIA to measure progesterone levels in milk.

Analysis Note

dextran coated charcoal 3H RIA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Kim Carnaby et al.
Reproduction (Cambridge, England), 144(4), 477-484 (2012-07-26)
Lynx presents a unique sexual cycle with persistent corpora lutea (CLs) and elevated serum progesterone (P₄) throughout parturition and lactation. In other mammals, CLs normally disintegrate after parturition, therefore the aim of our study was to characterise the annual life
Letizia Debertolis et al.
Journal of veterinary science, 17(2), 189-197 (2015-12-10)
This study was conducted to evaluate the effects of induced endometritis on uterine blood flow in cows. Transrectal Doppler sonography was performed on uterine arteries of six cyclic cows before and for 4 days after inducing acute endometritis by intrauterine
Alexandre Azevedo et al.
Conservation physiology, 8(1), coaa075-coaa075 (2020-08-28)
Knowledge on species' reproductive biology is a fundamental pre-requisite of every conservation effort, but is often lacking. Sex steroids can provide valuable information for the assessment of reproductive success, whereas glucocorticoids are used to assess adrenocortical activity and stress-related bodily
Fang-Ju Wu et al.
Reproduction (Cambridge, England), 159(3), 315-324 (2020-01-16)
Bone morphogenetic proteins (BMPs) are known to play an indispensable role in preventing the precocious luteinization of granulosa cells within growing ovarian follicles. In this study, we found that the transcripts of BMP8 genes are enriched in the ovaries of
Michał M Hryciuk et al.
Animals : an open access journal from MDPI, 11(1) (2021-01-21)
The objective of this study was to investigate the effect of luteinizing hormone (LH) on steroidogenic luteal cells obtained from corpora lutea (CL) of the domestic cat and selected wild felids. Luteal cells were isolated enzymatically from CL at different

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