P5806
Pasteurella multocida toxin
lyophilized powder
Synonym(s):
PMT
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About This Item
Form:
lyophilized powder
sterility
sterile-filtered
Quality Segment
form
lyophilized powder
packaging
vial of 50 μg toxin (Also contains 10 mM Tris, 0.1 M NaCl, and 0.1% sucrose, pH 8.3.)
storage temp.
−20°C
Biochem/physiol Actions
Pasteurella multocida toxin (PMT) is a bacterial protein toxin produced by few P. multocida serotype A and D strains. It acts as an effective mitogen in numerous cell types in vitro. PMT inhibits osteoblast differentiation by activating the Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway. Infections of PMT cause atrophic rhinitis in pigs and by local dermatonecrosis, respiratory disease in cattle and rabbits. PMT is also a pathogenic agent of dermatonecrosis and bacteremia in humans.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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