P6997
Anti-P2Y12 Platelet ADP Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-P2RY12, Anti-P2Y12
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7-58 μg/mL using human megakaryocytes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... P2RY12(64805)
mouse ... P2ry12(70839)
rat ... P2ry12(64803)
General description
P2Y12 Platelet ADP Receptor is co-expressed with the P2Y1 receptor on platelets leading to shape change, aggregation, and rise in intracellular calcium upon activation. P2Y12 has also been found in brain, spinal cord, and in vascular
Immunogen
synthetic peptide corresponding to the third cytoplasmic loop of human P2Y12 platelet ADP receptor, conjugated to KLH. The immunizing peptide has 83% homology with the rat gene and 89% homology with the mouse gene.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Instructions
Bernhard H Rauch et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2434-2442 (2010-11-13)
The platelet P2Y12 ADP receptor is a well-known target of thienopyridine-type antiplatelet drugs. This study is the first to describe increased transcriptional expression of a functionally active P2Y12 in response to thrombin in human vascular smooth muscle cells (SMC). On