R2778
RU 28362
≥98% (HPLC), solid
Synonym(s):
(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one
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About This Item
Empirical Formula (Hill Notation):
C23H28O3
CAS Number:
Molecular Weight:
352.47
UNSPSC Code:
51111800
PubChem Substance ID:
MDL number:
SMILES string
CC#C[C@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
assay
≥98% (HPLC)
form
solid
impurities
1.25 mol/mol Ethanol
solubility
DMSO: soluble 33 mg/mL
storage temp.
2-8°C
Gene Information
rat ... Nr3c1(24413)
Biochem/physiol Actions
Glucocorticoid receptor agonist.
Regulatory Information
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Xiao-Yi Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(21), 5602-5610 (2008-05-23)
Relapse to drug taking induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Previous studies indicate that drug seeking can be inhibited by disrupting the reconsolidation of a drug-related
Benno Roozendaal et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(3), 1328-1333 (2003-01-23)
Previous studies have indicated that stress-activated glucocorticoid hormones induce temporary memory retrieval impairment. The present study examined whether adrenal steroid receptors in the hippocampus mediate such glucocorticoid effects on spatial memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta, 17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one
Benno Roozendaal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(6), 1385-1392 (2004-02-13)
Previous findings indicate that the basolateral complex of the amygdala (BLA) interacts with other brain regions in regulating stress hormone effects on memory functions. Lesions of the BLA or infusions of a beta-adrenoceptor antagonist into the BLA block glucocorticoid effects
Igor Allaman et al.
Journal of neurochemistry, 88(4), 900-908 (2004-02-06)
Glucocorticoids (GC) are considered as key modulators of glycogen homeostasis in peripheral tissues, but their role in the central nervous system has only partially been characterized. Exposure of primary cultures of cortical astrocytes to dexamethasone (DEX), a synthetic glucocorticoid, results
M F Montaron et al.
The European journal of neuroscience, 18(11), 3105-3111 (2003-12-06)
The dentate gyrus is one of the few areas of the adult brain that continues to produce neurons and to express the embryonic polysialylated isoforms of neuronal cell adhesion molecules (PSA-NCAM). The stress hormone corticosterone exerts a complex modulation on
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