R2778
RU 28362
≥98% (HPLC), solid
Synonym(s):
(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one
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About This Item
Empirical Formula (Hill Notation):
C23H28O3
CAS Number:
Molecular Weight:
352.47
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
Assay
≥98% (HPLC)
form
solid
impurities
1.25 mol/mol Ethanol
solubility
DMSO: soluble 33 mg/mL
storage temp.
2-8°C
SMILES string
CC#C[C@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C
Gene Information
rat ... Nr3c1(24413)
Biochem/physiol Actions
Glucocorticoid receptor agonist.
Regulatory Information
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U S Sandau et al.
Neuroscience, 144(2), 482-494 (2006-11-18)
Neonatal administration of the synthetic glucocorticoid, dexamethasone (DEX) retards brain growth, alters adult behaviors and induces cell death in the rat brain, thereby implicating glucocorticoids as developmentally neuroendangering compounds. Glucocorticoids also increase expression of pro-apoptotic Bcl-2 family members and exacerbate
Taiki Takahashi et al.
Journal of neurochemistry, 83(6), 1441-1451 (2002-12-11)
This work reports the first demonstration that corticosterone (CORT) has a rapid and transient effect on NMDA receptor-mediated Ca2+ signaling in cultured rat hippocampal neurons. Using single cell Ca2+ imaging, CORT and agonists of glucocorticoid receptors were observed to modulate
Areg Barsegyan et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(38), 16655-16660 (2010-09-03)
It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effects on these two memory functions have generally been considered to be independently regulated
Benno Roozendaal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(45), 14299-14308 (2009-11-13)
Considerable evidence indicates that the basolateral complex of the amygdala (BLA) interacts with efferent brain regions in mediating glucocorticoid effects on memory consolidation. Here, we investigated whether glucocorticoid influences on the consolidation of memory for emotionally arousing training depend on
Abigail B Ginsberg et al.
Stress (Amsterdam, Netherlands), 13(3), 248-257 (2010-04-16)
The hypothalamic-pituitary-adrenal (HPA) axis self-regulates through a glucocorticoid negative feedback mechanism that is stereotypically slow and long lasting. Rapid (seconds to minutes) glucocorticoid feedback, however, inhibits stress-induced adrenocorticotropic hormone (ACTH) secretion too quickly to result from classic transcriptional effects of
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