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Merck
CN

S174

Sigma-Aldrich

SDZ-205,557 hydrochloride

solid

Synonym(s):

4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H21ClN2O3 · HCl
CAS Number:
137196-67-9
Molecular Weight:
337.24
MDL number:
MFCD00671790
UNSPSC Code:
12352200
PubChem Substance ID:
24278128
NACRES:
NA.77

Key Documents

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form

solid

color

off-white

solubility

DMSO: 100 mg/mL
H2O: 65 mg/mL
ethanol: insoluble

originator

Sandoz

SMILES string

Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC

InChI

1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H

InChI key

JOWUQCJWCRNVMQ-UHFFFAOYSA-N

Gene Information

human ... HTR4(3360)

Biochem/physiol Actions

Potent, selective 5-HT4 serotonin receptor antagonist.

Features and Benefits

This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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N Amemiya et al.
European journal of pharmacology, 318(2-3), 403-409 (1996-12-30)
This study examined effects of 5-methoxytryptamine (5-MOT), an agonist at 5-HT4 and 5-HT2B receptors, on the contractile response and acetylcholine release in rat stomach fundus strips. 5-MOT (10(-9)-10(-5) M) produced a concentration-dependent increase in the contraction, while it evoked acetylcholine
G E Torres et al.
The Journal of pharmacology and experimental therapeutics, 271(1), 255-261 (1994-10-01)
The study of serotonin-4 (5-HT4) receptors in the central nervous system has been hindered by the lack of effective, selective antagonists. However, recently, several novel compounds have been synthesized and shown to act as antagonists at 5-HT4 receptors in smooth
J Lorrain et al.
European journal of pharmacology, 229(1), 105-108 (1992-12-08)
Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by
J Coleman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 352(1), 74-78 (1995-07-01)
A putative 5-HT4 receptor-mediated depolarization of the rat isolated vagus nerve has been studied using a grease-gap extracellular recording technique. Ondansetron (1 microM) was used to block the predominant 5-HT3 receptor mediated depolarization in this preparation and the effects of
C M Franks et al.
The Journal of pharmacy and pharmacology, 47(3), 213-218 (1995-03-01)
The involvement of the recently characterized 5-HT4 receptor in the actions of 5-hydroxytryptamine (5-HT) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. 5-HT and the 5-HT1-, 5-HT2- and 5-HT4-receptor agonist 5-methoxytryptamine (5-MeOT), induced a
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