S3065
SC 19220
≥98% (HPLC), solid
Synonym(s):
2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C16H14N3O3Cl
CAS Number:
Molecular Weight:
331.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
color
white
mp
190-191 °C (lit.)
solubility
DMSO: soluble 10 mg/mL, H2O: insoluble
SMILES string
CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13
InChI
1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)
InChI key
KNURFLJTOUGOOQ-UHFFFAOYSA-N
Gene Information
human ... PTGER1(5731)
rat ... Ptger1(25637)
Application
SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.
Biochem/physiol Actions
EP1 Prostanoid receptor antagonist
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
H Inoue et al.
The Journal of endocrinology, 161(2), 231-236 (1999-05-13)
1,25 Dihydroxy vitamin D3 (1,25(OH)2D3), prostaglandin (PG) E2 and parathyroid hormone (PTH) induce osteoclast formation in cell cultures. Previously, we have shown that SC-19220, an antagonist of the EP1 subtype of PGE receptors, inhibited tartrate-resistant acid phosphatase (TRAP)-positive cell formation
Alexander V Timoshenko et al.
Experimental cell research, 289(2), 265-274 (2003-09-23)
Aberrant upregulation of COX-2 enzyme resulting in accumulation of PGE2 in a cancer cell environment is a marker for progression of many cancers, including breast cancer. Four subtypes of cell surface receptors (EP1, EP2, EP3, and EP4), which are coupled
K Oka et al.
The American journal of physiology, 275(6 Pt 2), R1762-R1765 (1998-12-09)
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S3065-10MG | 04061832786322 |
| S3065-50MG | 04061832786339 |