S6949
β-Synuclein V70M histidine-tagged human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Synonym(s):
SNCB
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
lyophilized powder
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... SNCB(6620)
Biochem/physiol Actions
Acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein.
Synucleins (α, β, γ-synoretin) are a family of small, highly conserved proteins expressed primarily in neurons and certain tumors. β-Synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of α-synuclein. It has been postulated that β-synuclein could act as a physiological inhibitor of α-synuclein aggregation and that it might protect the central nervous system from the neurotoxic effects of α-synuclein. The mechanisms of β-synuclein neuroprotection may involve direct interaction between β-synuclein and Akt, and thus suggest that this signaling pathway could be a therapeutic target for neurological conditions associated with Parkinson and α-synuclein aggregation. Overexpression of β-synuclein mutants (P123H and V70M) in neuroblastoma cells results in enhanced lysosomal pathology suggesting a causative role for these missense mutations in neurodegeneration stimulation.
Physical form
Lyophilized from a 0.2 μm filtered solution.
Preparation Note
Reconstitute with 0.5 mL water (~1 mg/mL). Store in working aliquots at −20 °C.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
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