S8690
SAHA
≥98% (HPLC)
Synonym(s):
N-hydroxy-N′-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat
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About This Item
Empirical Formula (Hill Notation):
C14H20N2O3
CAS Number:
Molecular Weight:
264.32
MDL number:
UNSPSC Code:
12352204
Assay
≥98% (HPLC)
color
white
solubility
DMSO: soluble ≥19 mg/mL
SMILES string
ONC(=O)CCCCCCC(=O)Nc1ccccc1
InChI
1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChI key
WAEXFXRVDQXREF-UHFFFAOYSA-N
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Biochem/physiol Actions
Potent, reversible pan-histone deacetylase (HDAC) inhibitor.
Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.
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Note: Unstable when in contact with metal, do not use metal spatula when weighing or transferring.
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Phillipp Kirfel et al.
Archives of insect biochemistry and physiology, 103(3), e21614-e21614 (2019-09-10)
Histone acetylation is an evolutionarily conserved epigenetic mechanism of eukaryotic gene regulation which is tightly controlled by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). In insects, life-history traits such as longevity and fecundity are severely affected
Jui-Hua Hsieh et al.
Chemical research in toxicology, 32(7), 1384-1401 (2019-06-28)
Genotoxicity is a critical component of a comprehensive toxicological profile. The Tox21 Program used five quantitative high-throughput screening (qHTS) assays measuring some aspect of DNA damage/repair to provide information on the genotoxic potential of over 10 000 compounds. Included were assays
Hoon Kim et al.
Scientific reports, 9(1), 9702-9702 (2019-07-06)
Cancer cell stemness is essential for enabling malignant progression and clonal evolution. Cancer cell fate is likely determined by complex mechanisms involving both cell-intrinsic pathways and stress signals from tumor microenvironment. In this study, we examined the role of the
Hunain Alam et al.
Cancer cell, 37(4), 599-617 (2020-04-04)
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a COMPASS-like enzyme, also called MLL4) is among the most highly inactivated epigenetic modifiers in lung cancer. Here, we show that
Mahesh Chemudupati et al.
Journal of virology, 94(16) (2020-05-29)
Butyrate is an abundant metabolite produced by gut microbiota. While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon
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