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SAB1306481

Sigma-Aldrich

ANTI-CD45(C-TERMINAL) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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Synonym(s):
CD45, Leukocyte common antigen, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

147254 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000

NCBI accession no.

NP_002829.3

UniProt accession no.

P08575

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTPRC(5788)

Related Categories

General description

Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 is expressed on T-cells and is found in multiple isoforms. The extracellular domain of the protein is predicted to have an amino-terminal mucin-like segment, a cysteine-rich domain and three fibronectin type 3 domains. The gene encoding this protein is localized on human chromosome 1q31.3.

Application

ANTI-CD45(C-TERMINAL) antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of janus kinases, CD45 inhibits cytokine receptor signaling.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Initiation of T cell signaling by CD45 segregation at `close-contacts?
Veronica T, et al.
Nature Immunology (2016)
CD45RO+ Memory T Lymphocytes ? a Candidate Marker for TNM-Immunoscore in Squamous Non?Small Cell Lung Cancer1
Erna-Elise Paulsen, et al.
Neoplasia (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario, et al.
Haematologica (2014)
Replication of association of the PTPRC gene with response to anti?tumor necrosis factor therapy in a large UK cohort*
Darren Plant, et al.
Arthritis & Rheumatology (Hoboken, N.J.) (2011)
Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases
Bao Yang, et al.
Oncology Letters (2017)
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