SAB1403268
Monoclonal Anti-SPA17 antibody produced in mouse
clone 3B6, purified immunoglobulin, buffered aqueous solution
Synonym(s):
SP17, SP17-1
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
3B6, monoclonal
Application:
ELISA (c), ELISA (i), WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3B6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~37 kDa
species reactivity
human
technique(s)
capture ELISA: suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SPA17(53340)
Related Categories
General description
Sperm autoantigenic protein 17 (SPA17) gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. SPA17 gene is located on human chromosome 11q24.2. This antigenic protein contains 151 amino acids and has a molecular weight of 17.4 kDa. This protein is highly expressed in testis and in somatic tissues.
Immunogen
SPA17 (NP_059121, 51 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEE
Sequence
EKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEE
Biochem/physiol Actions
Sperm autoantigenic protein 17 (SPA17) functions as a testis specific antigen. It also mediates signal transduction, protein synthesis and unregulated growth in proliferating and neoplastic cells. Overexpression of this protein decreases the resistance of epithelial ovarian carcinoma to chemotherapy. It regulates protein kinase A-independent AKAP (A-kinase anchoring proteins) complex in both germinal and somatic cells.160 The gene is associated with rheumatoid arthritis (RA).
Physical form
Solution in phosphate buffered saline, pH 7.4
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen
Coutinho-Camillo CM, ET AL.
Cancer Genetics and Cytogenetics, 166(2), 130-138 (2006)
Sperm protein 17 is expressed in the sperm fibrous sheath
Chiriva-Internati M, et al.
Journal of Translational Medicine, 7(1), 61-61 (2009)
Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells
Li FQ, et al.
BMC Cancer, 9(1), 323-323 (2009)
SPA17 (sperm autoantigenic protein 17)
Faried LS and Farie A
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2008)
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