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Merck
CN

SAB1410482

Sigma-Aldrich

Anti-CHRDL2 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

BNF1, CHL2, DKFZp586N2124, FKSG37

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 49.61 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC153100.1

UniProt accession no.

Q6WN34

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHRDL2(25884)

Related Categories

General description

CHRDL2 (Chordin-like 2) is a novel chordin-related gene belonging to the chordin family of proteins. It encodes a putative extracellular matrix protein consistsing of a signal peptide and three cysteine-rich (CR) domains. In humans, it expressed in several normal adult tissues predominantly in liver, heart, prostate, testis, and ovary.

Immunogen

CHRDL2 (AAI53101.1, 1 a.a. ~ 451 a.a) full-length human protein.

Sequence
MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWPPRRSLERLPSPDPGAEGHGQSRQSDQDITKT

Biochem/physiol Actions

CHRDL2 (Chordin-like 2) may play a role in the cartilage regeneration, myoblast and osteoblast differentiation. It has been reported that CHRDL2 may negatively regulate the cartilage formation/regeneration from immature mesenchymal cells. CHRDL2 restricts BMPs activity by blocking their interaction with its type I BMP receptor ectodomain. Overexpressed expression of CHRDL2 has been reported in several cancerous tissues such as breast, lung and colon cancers.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
11102

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Anat Oren et al.
Gene, 331, 17-31 (2004-04-20)
Chordin-like cysteine-rich repeats (CRs) are conserved domains present in an expanding family of secreted proteins that associate with members of the TGF beta superfamily. In this study, we report the molecular cloning and characterization of CHL2 (chordin-like 2), a novel
Inmin Wu et al.
Gene, 311, 105-110 (2003-07-11)
In an effort to identify novel genes relevant to tumor angiogenesis, we compared the genes expressed in a matched pair composed of vascularized breast tumor and its adjacent normal tissue obtained from the same cancer patient. Using differential display, we
Naoki Nakayama et al.
Development (Cambridge, England), 131(1), 229-240 (2003-12-09)
We have identified a novel chordin-like protein, CHL2, which is structurally most homologous to CHL/neuralin/ventroptin. When injected into Xenopus embryos, CHL2 RNA induced a secondary axis. Recombinant CHL2 protein interacted directly with BMPs in a competitive manner to prevent binding

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