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Merck
CN

SAB1411419

Sigma-Aldrich

Anti-OTUB2 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

C14orf137, FLJ21916, MGC3102, OTB2, OTU2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 27.2 kDa

species reactivity

human

technique(s)

immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

NM_023112.2

UniProt accession no.

Q96DC9

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OTUB2(78990)

Related Categories

General description

OTU ubiquitin aldehyde binding 2 (OTUB2) is a de-ubiquitinating enzyme, which belongs to the ovarian tumor protease (OTU) subfamily of deubiquitinylases. It has an ovarian tumor (OTU) domain. OTUB2 gene is mapped to human chromosome 14q32.

Immunogen

OTUB2 (NP_075601.1, 1 a.a. ~ 234 a.a) full-length human protein.

Sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH

Biochem/physiol Actions

OTU ubiquitin aldehyde binding 2 (OTUB2) possesses deubiquitinating enzymes (DUB) activity. It is capable of cleaving polyubiquitin chains, that are differently linked. It plays an important role in regulating the degradation of GLI family zinc finger 2 (Gli2) protein. OTUB2 can inhibit the death of human β cells. It is involved in immunity and viral infection. This protein can modulate nuclear factor κB (NF-κB) signaling pathway. OTUB2 might be associated with endometrial cancer.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
10169

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Dakshinamurthy Sivakumar et al.
The Journal of biological chemistry, 295(20), 6972-6982 (2020-04-09)
The ovarian tumor domain (OTU) deubiquitinylating cysteine proteases OTUB1 and OTUB2 (OTU ubiquitin aldehyde binding 1 and 2) are representative members of the OTU subfamily of deubiquitinylases. Deubiquitinylation critically regulates a multitude of important cellular processes, such as apoptosis, cell
A Beck et al.
Diabetologia, 56(6), 1317-1326 (2013-03-22)
Pro-inflammatory cytokines induce death of beta cells and hamper engraftment of transplanted islet mass. Our aim was to reveal novel genes involved in this process, as a platform for innovative therapeutic approaches. Small interfering RNA (siRNA) high-throughput screening (HTS) of
Carol A Edwards et al.
BMC evolutionary biology, 7, 157-157 (2007-09-08)
The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation
Xin-Yan Li et al.
Biochemical and biophysical research communications, 505(1), 113-118 (2018-09-23)
The transcription factor Gli2 plays crucial roles in the transduction of Hedgehog (Hh) signals, yet the mechanisms that control Gli2 degradation remain unclear. Here we have identified the eubiquitinating enzyme otubain2 (OTUB2) as a regulator of Gli2 protein degradation. We

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