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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

UniProt accession no.

Q8IUC6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TICAM1(148022)

General description

Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.

Immunogen

Synthetic peptide from human TICAM1 / TRIF.

Biochem/physiol Actions

Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
21676
5365

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