SAB3500199
Anti-Clusterin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ApoJ, Anti-Apolipoprotein J, Anti-CLI, Anti-Complement lysis inhibitor
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
7
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLU(1191)
General description
The Clusterin (CLU) gene is mapped to human chromosome 8p21.1. The encoded protein is a chaperone and is conserved along with evolution. It is present in human tissues and fluids.
Immunogen
Clusterin antibody was raised recombinant human Clusterin isoform 1.
Application
Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100).
Biochem/physiol Actions
Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small heat shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimer′s disease (LOAD).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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