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SAB4200101

Anti-AS160 antibody produced in rabbit

Name: Anti-AS160 antibody produced in rabbit
Brand: SIGMA

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-Akt substrate of 160 kDa, Anti-TBC1D4 (TBC1 domain family, member 4)

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~160 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

indirect immunofluorescence: 8-16 μg/mL using HEK-293T cells, western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells over expressing human AS160

UniProt accession no.

O60343

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TBC1D4(9882)
mouse ... Tbc1d4(210789)

Description

General description

AS160 (Akt substrate of 160 kDa, also known as TBC1 domain family member 4 (TBC1D4)) gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating proteins (RabGAP) protein. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.

Application

Anti-AS160 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

AS160 is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. It is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品

低风险生物材料

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Certificates of Analysis (COA)

Lot/Batch Number

020M4801

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Global Trade Item Number

SKU	GTIN
SAB4200101-25UL	04061838034557
SAB4200101-200UL	04061838034540