SAB4300689
Anti-ABCG2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-ABC15, Anti-ABCP, Anti-BMDP, Anti-CD338, Anti-MRX
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
65-80 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(R-I-N-R-V)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ABCG2(9429)
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General description
The ABCG2 (ATP binding cassette subfamily G member 2) gene encodes an ATP-binding cassette (ABC) transporter that is also called as breast cancer resistance protein (BRCP). It is composed of 655 amino-acids and is located on human chromosome 4q22. It belongs to the ABCG (white) subfamily.
The antibody detects endogenous level of total ABCG2(CD338) protein.
The antibody detects endogenous level of total ABCG2(CD338) protein.
Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Immunogen
Peptide sequence around aa. 160-164 ( R-I-N-R-V), according to the protein NP_004818.2
Biochem/physiol Actions
ABCG2 (ATP binding cassette subfamily G member 2) serves as a shield for several tissues against xenobiotic molecules. It can provide multidrug resistance (MDR) in breast and other cell lines.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kinetic Modeling of ABCG2 Transporter Heterogeneity: A Quantitative, Single-Cell Analysis of the Side Population Assay
Prasanphanich AF, et al.
PLoS Computational Biology (2016)
Structure of the human multidrug transporter ABCG2
Taylor NMI, et al.
Nature (2017)
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
Doyle L and Ross DD
Oncogene (2003)
Gayathri Heenatigala Palliyage et al.
Lung cancer (Amsterdam, Netherlands), 181, 107258-107258 (2023-05-29)
A cure for cancer is out of reach for most patients due to chemoresistance. Cancer-associated fibroblasts (CAFs) play a vital role in cancer chemoresistance, but detailed understanding of the process particularly in chemoresistant lung cancer is lacking. In this study
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