SAB4501569
Anti-IRS-1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
IRS-1, IRS1, Insulin receptor substrate-1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 131 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IRS1(3667)
General description
Anti-IRS-1 Antibody detects endogenous levels of total IRS-1 protein.
Insulin receptor substrate 1 (IRS1) belongs to the IRS family. It is mapped to human chromosome 2q36.
Immunogen
The antiserum was produced against synthesized peptide derived from human IRS-1.
Immunogen Range: 289-338
Immunogen Range: 289-338
Biochem/physiol Actions
Insulin receptor substrate 1 (IRS1) participates in the insulin signaling pathway. It is associated with type 2 diabetes (T2D). IRS1 regulates glucose homeostasis, body growth and peripheral insulin action.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos.
Qi Q, et al.
Obesity (Silver Spring, Md.), 24(11), 2407-2413 (2016)
The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.
Sharma R, et al.
Atherosclerosis, 216(1), 157-160 (2011)
Association between IRS1 Gene Polymorphism and Autism Spectrum Disorder: A Pilot Case-Control Study in Korean Males.
Park HJ, et al.
International Journal of Molecular Sciences, 17(8), 1227-1227 (2016)
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