SAB4502022
Anti-NOTCH2 (Cleaved-Val1697) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
7
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 83 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Val1697)
Gene Information
human ... NOTCH2(4853)
General description
Anti-NOTCH2 (Cleaved-Val1697) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Val1697) protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human NOTCH2.
Immunogen Range: 1678-1727
Immunogen Range: 1678-1727
Biochem/physiol Actions
The NOTCH2 gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Domenica Giannandrea et al.
Haematologica, 107(9), 2183-2194 (2022-03-11)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events associated
Michela Colombo et al.
Haematologica, 105(7), 1925-1936 (2019-10-05)
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to the interactions of malignant plasma cells with the bone marrow (BM) microenvironment. Myeloma cells educate BM cells to support neoplastic cell growth, survival, acquisition of drug
Kai Dai et al.
Frontiers in immunology, 8, 320-320 (2017-04-07)
The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4502022-100UG | 04061837174131 |